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Neurobiology of Mood & Psychotic Disorders


The research line Neurobiology of Mood & Psychotic Disorders leverages neuroscience and genomics towards an understanding of the pathophysiology of psychiatric illness.

This research program focuses on advancing the pathophysiological understanding and treatment of mood and psychotic disorders, in terms of both clinical pathophysiology and fundamental cellular mechanisms.

Our consistent approach has been to participate in collaborative research programs both within the Erasmus MC and (inter)nationally, with a shared goal to discover novel clinical treatments. This allows clinicians and clinical researchers to work side-by-side with neuroscientists, geneticists and epidemiologists to study mental illnesses from their genetic basis to behavioural manifestations.

We are keen to leverage the rapid technological achievements in human genetics, pluripotent stem cell modelling and genome editing. These achievements help to make significant advances in the diagnosis, treatment and prevention of mental illness using a precision medicine approach.
GEZIN study

The GEZIN study

We use a combination of human pluripotent stem cell modelling and transgenic animal models to investigate the underlying functional impact of the identified variants in order to gain pathophysiological insight, clarify diagnostic pathogenicity and uncover novel therapeutic targets.

The OPPER study

The OPPER study is the world largest cohort of first-onset postpartum psychosis, and includes both longitudinal clinical assessments and biological studies.

Research groups
Kushner lab

Biology of mental illness (Kushner lab)

The underlying neurobiology of psychiatric disorders remains largely enigmatic, owing to a combination of the complexity of the central nervous system as well as technical limitations in studying the brain.
Peripartum Mental Disorders

Peripartum Mental Disorders

The main focus of research of the Peripartum Mental Disorders group is the neurobiology and phenomenology of postpartum psychosis.

Major Depressive Disorders

Major Depressive Disorders

The Major Depressive Disorders group has done and continues to do research on the efficacy of neurobiological interventions, like psychopharmacological and electroconvulsive therapy.


Due to the summer holidays there’re no Wetenschapslunch Psychiatry meetings scheduled in July and August.


The first meeting after the summer will take place on:

Monday, September 2nd, 2024
at 12 h




Sabine Rosa