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The difference between stupidity and genius is that genius has its limits.
-Malcolm Forbes
The chief function of the body is to carry the brain around.
-Albert Einstein
Brain: an apparatus with which we think we think.
-Ambrose Bierce
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Research - Psychiatry

Mission statement

Our mission is to innovate and optimise the diagnosis, treatment and prevention of severe mental health disorders in a medical context. The research conducted herein comprises applied, clinical and translational studies.

 

News

3D MICrobrains maken medicijntesten in humane hersencellen mogelijk

Posted by Admin on December 2021

opgekweekte hersenorganoïde

Neurobiologen Femke de Vrij en Steven Kushner hebben 1 miljoen euro subsidie gekregen voor de ontwikkeling van doelmatige humane hersenorganoïden. Met het geld gaan ze de komende 5 jaar humane 3D MICrobrains ontwikkelen én wetenschappelijk aantonen dat er betrouwbare medicijntests op kunnen worden uitgevoerd.

De medicijnwaakhonden FDA (Verenigde Staten) en EMA (Europa) eisen vrijwel altijd eerst resultaten van proefdieronderzoek voordat een nieuw geneesmiddel bij mensen mag worden getest. Diermodellen zijn echter niet altijd voldoende voorspellend voor de fysiologie van de mens. De hersenorganoïden hebben de potentie om een betrouwbaar en beter voorspellend alternatief te worden voor proefdieronderzoek naar nieuwe medicatie voor neurologische en psychiatrische ziekten.

Lees meer: Amazing Erasmus MC

Jaarverslag
Wetenschappelijk onderzoek, Afdeling Psychiatrie, Erasmus MC

Posted by Admin on November 2021

Erasmus MC building

Het wetenschappelijk onderzoek van de afdeling Psychiatrie bestaat uit toegepast onderzoek en translationeel onderzoek naar psychotische- en stemmingsstoornissen.

Het toegepaste onderzoek beoogt concrete antwoorden te geven op vragen over ... picture_as_pdf Lees meer

'Making big data meaningful for a promising start in the first 1000 days of life'.

Posted by Admin on July 2021

stem cell research

Mijke Lambregtse-van den Berg is one of the work package leaders of a consortium led by Tanja Houweling from Public Health that has been awarded 1,3M euro from the NWO research agenda ‘Promising start for children with the help of big data.

All children deserve a promising start. Most children are doing fine. But some need extra support, because of problems during pregnancy, or because they grow up in disadvantaged circumstances, e.g. due to poverty or parental addiction or mental health problems. In this multidisciplinary project, we study how relevant datasets, among others of Statistics Netherlands, can be used to support these children and (expectant) parents. By ensuring more timely referral to services that meet their needs. And by tailoring municipal polities to the needs of vulnerable children and (expectant) parents. We collaborate with parents, practitioners and municipalities to ensure our research meets their priorities. This collaborative project includes partners from the Department of Public Health (Erasmus MC), the Departments of Psychiatry and Child and Adolescent Psychiatry/Psychology (Erasmus MC), the Leiden Institute of Advanced Computer Science, the City of Rotterdam, and a broad range of societal partners.

Mijke will lead the work package that focusses on consultation and participation of involved families, practitioners and policy makers to ensure the project meets their needs and concerns. In this work package also prognostic models from other work packages will be used to develop and test a dynamic tool for identification that can be integrated in existing online screening tools and digital personal health environments to guide (expectant) parents and their towards tailored interventions.

Major ZonMw investment for stem cell research into neuropsychiatric disorders.

Posted by Admin on July 2021

stem cell research

The Departments of Psychiatry and Clinical Genetics at Erasmus MC lead a consortium project recently funded by ZonMw's PSIDER program using human pluripotent stem cells to develop an innovative platform of therapeutic discovery for hereditary neurodevelopmental disorders.

Steven Kushner of the Department of Psychiatry and Ype Elgersma of the Department of Clinical Genetics, lead the project Towards a human iPSC neuronal platform for neurodevelopmental disorder therapeutic discovery, which was awarded 4 million euros. Femke de Vrij (Psychiatry) and Marjon van Slegtenhorst (Clinical Genetics) of Erasmus MC also participate in the consortium.

The project will identify patients who have a severe cognitive developmental disorder due to a genetic mutation. If the mutation is suitable for correction with so-called antisense oligonucleotide (ASO) therapy, stem cells are generated from blood cells of the patient. These stem cells will be differentiated into brain cells, on which the mutation-specific ASO will be tested for therapeutic rescue of disease-associated molecular and cellular phenotypes. The researchers expect this research to be the prelude to routinely developing personalized therapies for a large group of rare neuropsychiatric disorders that are currently untreatable.

The ZonMw program Pluripotent Stem cells for Inherited Diseases and Embryonic Research (PSIDER) is intended for biomedical research with induced pluripotent stem cells. Within the program, ethical, legal and social issues are a strong focus

Astrid Kamperman received a grant of 50.000 Euro of the EUR Trustfonds for the study 'Addressing the victim in the room'!

Posted by Admin on June 2021

Domestic violence

Domestic violence is an ordinarily highly prevalent phenomenon. Families in which domestic violence is present suffer from both physical and emotional trauma, straining the family unit and sometimes resulting in the death of a family member. At the same time, the presence of domestic violence often remains undetected and unaddressed by health care professionals. We propose the use of newly emerging machine learning techniques to address this need.
In line with the NWO Artificial Intelligence Research Agenda for the Netherlands we view AI as a socio-technical system, in which technological and societal aspects of AI are inherently intertwined. In this project, we will include a technical and a social component, developed in close interaction. In the technical component, we will leverage the information standardly contained within patient electronic patient files, where rich data is collected from structured fields and unstructured clinician notes. With regard to the social component, we will explore the acceptability and legitimacy of using an AI application to detect domestic violence in mental health care. The finance will be used to study of the social component of the development and implementation of this ML algorithm in mental health care. Acceptability and legitimacy will be studied using focus groups. Focus groups will be organized such to optimally assess the perspectives of clients, clinicians, data-scientists, privacy officers and legal staff, and managerial staff.

This pilot project is a collaboration between academic and societal partners, i.e. the EMC (Dept of Psychiatry), EUR (ESHPM), Delft University of Technology (Dep of Human-Centered Design), UMC Utrecht (COVIDA, PsyData), regional mental health care institutes (Antes and BavoEuropoort/Parnassia Groep, GGZ Delfland), and patient representatives (MIND).
Seminar

Lunch meeting Psychiatry
by zoom
Monday, January 24, 2022
at 12 h


SeminarsQuote Single-cell RNA sequencing of astrocytes and neurons derived from human induced pluripotent stem cells.


Presenter: Maurits Unkel (GEZIN)


 

Kushner lab Biology of mental illness
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Kushner Lab

 

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